Vitamin B1(thiamine, often found in B complex vitamin supplements) is an essentiel nutrient required for proper brain functioning. Thiamine deficiency is associated with many acute brain diseases and conditions such as Wernicke’s Encephalopathy, Korsakoff’s Psychosis, and cerebellar degeneration – all three as serious as they sound! In developed countries where people generally have good nutrition thiamine deficiency is relatively rare. Vitamin B1 deficiency can present, however, with higher than average alcohol consumption. Read more

Vitamin B3 (nicotinomide, one of the vitamins found in our B Complex) is necessary for the proper use of sugars and fats in the body in the maintenance of cellular health.

In their article Cell Life Versus Cell Longevity: The Mysteries Surrounding Nicotinamide (US National Library of Medicine) Li et al. have predicted further studies of vitamin B3 and it’s interactions on our bodies will lead to development of therapies for diabetes as well as a host of other concerns including: aging, Alzheimer’s disease, cerebral ischemia, Parkinson’s disease, and cancer. Read more

best injectable vitamin b12

Injectable vitamin B12 is available as a supplement in several forms, each with it’s own advantages and disadvantages.  Learning about each will help you decide which of these forms is best for you.  As always, you should consult your health professional when making health related decisions.

The different forms of vitamin B12 are collectively called cobalamins because they share in common the mineral cobalt. These various cobalamins are converted by your body into methylcobalamin and 5-deoxyadenosylcobalamin, the forms of vitamin B12 that are active in human metabolism.

The Different Forms of Vitamin B12 Cobalamin

Injectable vitamin B12 supplements are available in 3 common types. Existing evidence does not suggest any differences among forms with respect to absorption or bioavailability. Read more

An interesting study conducted in Paris hospitals with 14k participants aged 50-90 years.  Vitamin B12 deficiency is found to increase with age –  “functional B12 deficiency was 9.6% in patients aged 30-60 years and 14.2% in patients over 90 years”.

BACKGROUND: Cobalamin deficiency is responsible for hematological, neurological, neurocognitive, and neuropsychiatric impairments and is a risk factor for cardiovascular diseases, particularly in the elderly people.

METHODS: In order to determine B12 status in old inpatients, a total number of 14,904 hospitalized patients in whom B12 measurements were performed in five hospitals in the Paris metropolitan area were included from January 1, 2011 to December 31, 2011. The aims of the study were to determine whether age had an impact on B12 and folate deficiencies and to evaluate correlations between B12 and biological parameters-folate, hemoglobin, mean cell volume, homocystein (tHcy)-and age.

RESULTS: Patients were aged 70.3±19.5 years. Low B12 concentration (<200ng/L) was observed in 4.6% of cases, 24.2% had middle B12 concentration (200-350ng/L), 12.6% were functional B12 deficient (B12 < 350 ng/L associated to high tHcy level, tHcy > 17 µmol/L), 20.4% had low folate concentration (folate < 4 µg/L), 10.6% were functional folate deficient (folate < 4 µg/L associated to tHcy > 17 µmol/L), and 4.7% of patients were both functional B12 and folate deficient. …  Frequency of functional B12 deficiency was 9.6% in patients aged 30-60 years and 14.2% in patients over 90 years. Frequency of functional folate deficiency was 9.5% in 30-60 years and 12.1% in >90 years.

CONCLUSIONS: In inpatients, functional B12 deficiency and functional folate deficiency increase with age and are not associated with anemia or macrocytosis. False vitamin B deficiencies are frequent.

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